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MIF also has the capability to interact with p53, decreasing the expression of p21 and BAX, which results in crucial mobile proliferation. MIF may also immediately communicate with CXCR2 and CXCR4, which end in inflammatory action and leukocyte chemotaxis.
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MIF has different Organic roles, Using the most important currently being inflammation and immunity. MIF counter-regulates the actions of glucocorticoids, which can be pure steroid hormones produced by the adrenal glands all through mobile strain that have anti-inflammatory effects [5]. MIF may promote the expression of other cytokines linked to inflammation. Inflammation is needed for that survival of organisms, but when it truly is improperly controlled, it may well add to tumorigenesis [six].
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